Dwayne Haskins had a career passing performance, throwing for 455 yards and six touchdowns, but fell just three yards shy Art Schlichter's single-game passing record.
Ohio State didn't pull away until the fourth quarter, but ultimately took care of business against Indiana, led by a school record-tying six touchdown passes from Dwayne Haskins.
50 years after Dr. Martin Luther King Jr.'s death, the Ohio State Marching Band honored the civil rights movements with its halftime performance during the Indiana game.
Coming off a fourth-quarter comeback win over Penn State for the second consecutive year, Ohio State looks to avoid a letdown as it hosts the Hoosiers on Saturday.
It will be unseasonably warm for Indiana's visit to Columbus to take on No. 3 Ohio State Saturday – with a slight chance of showers throughout the day.
Ohio State outshot No. 8 Colgate 22-7 in the middle frame and Lauren Boyle capped off a furious scoring rally as the Buckeyes collected a statement win.