The Buckeyes open as a three-touchdown favorite in this week's top-10 showdown.
Ahead of No. 3 Ohio State's matchup with No. 10 Indiana next week, the Buckeyes open as a 21-point favorite over the Hoosiers with the game total set at 64.5 on Circa Sports.
This marks the third time Ohio State has opened as a favorite of three or more touchdowns this season. Ohio State failed to cover a 38-point spread against Rutgers the last time the Buckeyes were in action and didn't play this week's matchup against Maryland after opening as a 27-point favorite.
So far this season, Ohio State is 2-1 against the spread, covering against both Nebraska and Penn State to start the season before missing the cover against the Scarlet Knights.
Some other notable lines in the Big Ten include Michigan opening as a 10-point favorite on the road against Rutgers and Wisconsin opening as an 8-point favorite against Northwestern in a top-25 showdown between unbeaten Big Ten West teams.