This week's question is inspired by one that I saw on a r/CFB thread and thought it might provoke some interesting #takes.
I believe that you can answer this question in one of two ways. You either choose a difficult opponent who may have ruined a season, or a team that seems like a waste of time — I'm looking at you, Rutgers. Either way, it's permanent so choose wisely.
Personally, I would be totally fine if Ohio State never played Iowa again. The loss in Iowa City in 2017 is still burned within my memory but other than that, most games I've witnessed against Iowa have been a snooze-fest.
So for me, never playing Iowa again is the best of both worlds.