Derrick Henry carried the ball 46 times for Bama on Saturday. All-time NFL record? 45 carries by Jamie Morris in 1988. Link:

http://www.pro-football-reference.com/leaders/rush_att_single_game.htm

Many studies on the over-use of running backs exist. Good article on the subject (and the fall-off of an RB's effectiveness after a season of overuse):

http://www.footballdocs.com/running_back_carries.html

MOD EDIT - Closing thread, "agree to disagree" gif.