| Tipoff (ET) | MATCHUP | TV | Region | Location | Favorite |
|---|---|---|---|---|---|
| 6:50 PM | #9 St Louis v #8 Memphis | TBS | West | Columbus, OH | MEM (-3) |
| 7:15 PM | #15 Lehigh v #2 Duke | CBS | South | Greensboro, NC | DUKE (-12.5) |
| 7:20 PM | #13 Ohio v #4 Michigan | TNT | Midwest | Nashville, NC | UM (-6) |
| 7:27 PM | #10 Purdue v #7 St Mary's | truTV | Midwest | Omaha, NE | MARY (-2) |
| 9:20 PM | #16 Long Island v #1 Michigan St | TBS | West | Columbus, OH | MSU (-20) |
| 9:45 PM | #10 Xavier v #7 Notre Dame | CBS | South | Greensboro, NC | ND (-2.5) |
| 9:50 PM | #12 USF v #5 Temple | TNT | Midwest | Nashville, TN | TEMP (-3) |
| 9:57 PM | #15 Detroit v #2 Kansas | truTV | Midwest | Omaha, NE | KAN (-14) |
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