The most obvious choices have to be Zeke's 85 yard run vs. Alabama, the Pass interference call with Gamble Gamble, and Holy Buckeye due to the magnitude of the play and the eventual outcomes. But what other play from this century stands out in your mind whenever you think Ohio State football. 

For me, it is Troy Smith's touchdown to Brian Robiske vs. Penn State in 2006. At the time I was a 10 year old kid and Troy Smith was my hero. Being 10 years old, Smith's celebration was something I would imitate during recess football games for the next year.