Pittsburgh Steelers vs Buffalo Bills Live. The Pittsburgh Steelers and the Buffalo Bills will face off at 1 p.m. ET Sept. 12 at Highmark Stadium to kick off their 2021 seasons. Pittsburgh is coming off of a 12-4 season with hopes of advancing further than the first round of the playoffs, where they were eliminated by the Cleveland Browns 48-37. Buffalo advanced two rounds further, losing to the Kansas City Chiefs 38-24 in the Conference Championship.

A couple last-season offensive stats to keep in the back of your head while watching: The Steelers ranked worst with respect to rushing yards per game last season, where the squad accrued only 84.4 on average. Buffalo's offense has more to brag about, as they they were second best in yards per game, finishing the 2020 season with 396.4 on average.

The Pittsburgh sideline is surely aware that they're the underdogs in this one. Perhaps they'll be able to flip the script and come out with a big win.

How To Watch
When: Sunday at 1 p.m. ET
Where: Highmark Stadium -- Orchard Park, New York
TV:

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Online streaming
Follow: CBS Sports App
Odds
The Bills are a solid 6.5-point favorite against the Steelers, according to the latest NFL odds.

Over/Under: -110

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Series History
Buffalo have won two out of their last three games against Pittsburgh.

Dec 13, 2020 - Buffalo 26 vs. Pittsburgh 15
Dec 15, 2019 - Buffalo 17 vs. Pittsburgh 10
Dec 11, 2016 - Pittsburgh 27 vs. Buffalo 20