This Curtiss air-cooled V8, with builder Glenn Cutiss riding, went 136.3 mph over the measured mile at Ormond Beach, Florida, on Jan. 23, 1907.  It was not only the fastest speed ever attained by a motorcycle, but the fast by any vehicle. Curtiss’ run on Ormond Beach was astonishing for the time. His outright speed record held for 12 years and it took 23 years for a motorcycle to go faster. Curtiss’ massive V8 was essentially a 4000cc beast built on a beefy bicycle frame.

From website, Rider Files, 1/31/2010, Larry Lawrence

This engine was the forerunner of the (503 c.i.) Curtiss OX-5 which powered the JN-5 aircraft - the "Model-T" of American air planes.