BetOnline released opening lines for each of the Big Ten's Week 1 games on Thursday, and Ohio State opened as a 21.5-point favorite for its Oct. 24 game against Nebraska at Ohio Stadium.

The Buckeyes, who currently hold the second-best national championship odds (+300) and are a -500 favorite to win the Big Ten on BetOnline, are one of two Big Ten teams favored to win their season openers by more than three touchdowns, along with Wisconsin (-23.5) over Illinois.

Ohio State defeated Nebraska 48-7 in their matchup in Lincoln last season. In their annual matchups since 2016, Ohio State has won three of its four games against Nebraska by at least 41 points; the only close game between the Buckeyes and Cornhuskers in the past four years came in 2018, when Ohio State won 36-31.