Chris Holtmann's squad will be an underdog to start the season as Cincinnati is a 5.5-point favorite against the Buckeyes in Wednesday's season opener, according to Vegas Insider.

Ohio State travels to face Cincinnati on Wednesday, marking the first time the two schools have met in the state of Ohio since 1921 – almost 100 years.

It'll be a new-look Buckeye team as they look to replace three starters and their top-two scorers from last season, including 2018 NBA Draft pick Keita Bates-Diop.

The game tips off from Cincinnati at 6 p.m. on ESPN2.