The university system as it stands is probably facing it's most grave challenge to their existence. There have been cultural trends in recent years going against universities. Enrollment went down at universities in the 2010's. What has happened in 2020 is going to compound it.
There have been concerns in Columbus about enrollment drops going forward. Places like Ohio State and Columbus State can probably adjust. It is the smaller schools that will have trouble. It will impact cities like Columbus, but it will be worse in MAC college towns (Athens, Oxford, Bowling Green) or small school towns (Gambier, Ada).