The only real change that needs to happen is taking concussions seriously.
I don't think that means changes to the rules, per se. I think it means changing how we teach tackling, and changing the culture of "toughness" when it comes to head injuries.
We've got to emphasize with these kids that if they're injured, they need to worry about their future, not the game. And we're have to have the ADULTS in the situation pushing for that as well.
I don't have any problem with my kids playing football for a coach who looks after their health. I'm terrified about them playing or a coach who tells them to shrug it off, or (knowing what we know now) throws them back in the game when the entire stadium can see they just got knocked out.
From what I've seen about the research, if you listen to your body, you're not going to end up with degenerative brain disease from playing some high school (or even college) football. It'll mean more guys like Reeves hanging things up when they start having symptoms -- but plenty of guys have to hang up their cleats for other injuries as well. Having had ACL surgery myself, I'm honestly still more worried about kids not being able to walk right. But what is living if you don't challenge your body occasionally?