My favorite memory of a game that meant very little in the grand scheme thing of things might be the season opener against Northern Illinois in 2006.
My first season as a Buckeye fan was 1994, when I was 9 years old, so my fist 5 years of fanhood were blessed with amazingly talented and potent offenses that had no problem putting inferior opponents' throats under its foot. After 1998, those days seemed to disappear. Despite there being some great seasons between 1998 and 2006, the absence of a complete and dominant offense made football Saturdays much more stressful than what I was used to from childhood.
The 3 incredibly easy looking touchdown passes in the first quarter against Northern Illinois in 2006 signaled to me that for that season at least, the lackluster passing game, close games against unworthy competition, and slow starts to a season were gone. That season was so stress free. It was so wonderful until, well, nevermind. I think 2010 might be the first such season since 2006. I hope nothing spoils it this time.