Look at who has beaten Ohio State in big, night games in the recent past: Texas and USC.
Texas had a freak at QB, our TE dropped a TD pass, there was confusion about whether Zwick or Smith was the better QB, JT played Tresselball - and still, it took a last minute drive by the freak to beat Ohio State.
USC had a young, but very talented Matt Barkley at QB, Pete Carroll on the sidelines, Ohio State played Tresselball and kept it close - and still, it took a last minute drive to beat Ohio State.
Gentlemen, Va Tech has a wonderful man for a head coach, and talented players and coaching staff. They must be respected, BUT Va Tech is nowhere near Texas or USC as a program, Ohio State will not (better not) be playing Tresselball: running Dave on first and second down and being ecstatic to punt.
Point is: it takes a very strong program to win in that stadium, at that time of day, in that environment. I don't think Va Tech is that kind of opponent.
That said, the ball is oblong, it bounces funny, fluke events happen, and if those go Va Tech's way and lead to a win for them, you congratulate them on their good luck, and then start mourning. But given the factors above, I think the odds are that we are all going to be happy when it's all over.