One thing I noted on twitter, and can expand on a bit, is the scheme.
Meyer likes to get guys into routes. 7-man protections are rarely an option for him; if he can get 5 guys into routes he's going to get 5 guys into routes. It makes sense, it's a basic tenet of the spread offense: spread the field vertically and horizontally. The more guys in routes, the more you can stretch the field and space the defense. More routes holds the defense in their coverage and makes the QB's reads easier and allows receivers to run their routes into more space. Meyer uses routes that are essentially designed to control the defense, or force them to respect routes that aren't necessarily options. Flare control and safety controlling routes to open up the field elsewhere.
But the more you spread the field, and the more guys you put into routes, the fewer options you have in pass protection. That means in terms of numbers, schemes, adjustments, etc. All those things are still a part of OSU's offense, but to a lesser extent than say an MSU team (which had one of the best sack rates in college football). That keeps the offense simpler for the O-line, TE, and RBs in terms of pass pro, but gives you fewer options. If the defense can reduce space (good coverage, good pressure scheme), there aren't a lot of options for the OSU QBs, who are forced to either take off or get sacked.
So it's about weighing the positives and the negatives. Meyer believes that it is a greater benefit to be able to control the defense and make the QB's reads easier by running play action (prevents the defense from getting quickly into its pass rush and forces the hand), control routes, simple concepts with simple QB reads, and that mitigates a lot of the inherent negatives of getting sacked every once in a while.
To top it off, often times the running QB is the "3rd option" in the pass game. His taking off is as dangerous or more dangerous than a check down throw. This is true in many extents, but it can lead to sacks because the QB has the ball in his hands more, but also because he is dropping his eyes.
So OSU has a few options: they can switch up pass protections more (this isn't going to happen, I'll tell you that right now); they can switch up how they release into routes from blocks (this may happen), they can improve the QB's feel for those check downs and when to look for them (probable), they can improve the QB's understanding of escape paths which are designed into every protection scheme (quite likely).
But more than anything, it's about getting the ball out on time. One thing all the spacing allows for OSU's QBs is to be late with a lot of their reads and still have the read be correct. When Jones came on, Meyer really simplified the reads to enforce the fact that the ball was going to come out on time; he did this with very simple concepts to the outside of the field, things like tunnel screens, bubble screens, and 60-Y Curl that they ran extensively against Wisconsin. But the more film a defense has a guy, the more you need to expand it. And when you expand it, the reads have to get a little more difficult, and it's about getting the ball out on time. That means throwing into some tighter windows at times, or throwing guys open, but still making the correct read and the correct throw. That will be the primary focus for the OSU coaches, IMO, to improve the sack rate.