Yes. First game of the season and OSU will be breaking in a new right tackle. While not nearly as big a change as replacing 80% of the line it only takes a breakdown at one position in the line, either in execution or communication. VT's ends are good and the Hokies will probably be coming in at full strength. I have no doubt that, if healthy, Chase Farris will be performing at a high level this season but it may not necessarily be the case in the first game. It may not be raw Taylor Decker versus Khalil Mack, but Farris will be facing very high quality counterparts.
I don't think the Bucks will put up the numbers on O that many seem to be anticipating. OTOH, barring turnovers and special teams breakdowns, I do expect VT to find the points much more difficult to come by this year. Last year their QB seemed to have his game of the season and he just barely got away with some ill-advised throws. Something like that should not happen this year.