I actually expect a lot of the same aggressive schemes with safeties in the box to help against the run. With split reps at QB in practice, and only one real returning wide receiver that has experience playing the position, I'd bet on my DB's against the OSU passing game rather than let Zeke and the Slobs run through my front. VT doesn't always have the best talent from a recruiting standpoint, but they are EXCELLENT teachers of secondary play, and that can make up for any talent gap between them and a guy like Braxton or Curtis Samuel.
If anything changes, I can see Va Tech throwing out some funny looks up front to confuse the OL if possible. Otherwise I'd bet the farm on aggressive pass D to let the safeties assist in the run game.