I don't play much anymore but I used to play a lot and all my vacations were planned around trying a different golf course usually.
The top ones Ive played in no particular order;
TPC Sawgrass, Atlanta Athletic Club, East Lake, Bandon Dunes, Ocean Course at Kiawah, Bethpage Black, Whistling Straits, Torrey Pines, Ocean Club at Sea Island, Greyhawk in Scottsdale, Ghost Creek in Portland, Scarlet Course and Pinehurst.
The best golf experience I had ever was on a course right off Kiawah called Cassique. Very exclusive, one of about ten groups on the course all with our own caddies. No blade of grass was unattended to.
Finishing birdie birdie birdie par on Sawgrass to shoot 77 was without a doubt the best result on all the courses. Though it was about the 5th or 6th time Id played Sawgrass most of the others I only played once. Bogeying 18 for an 80 at Bethpage was my best first time effort