Missouri went to Indiana last season. Undoubtedly that was scheduled with Indiana's weakness in mind. It was made easier by the fact that Mizzou and Indiana had a mini rivalry from '85-'92 where they played each year back when Mizzou was in the Big 8. UK and IU also played every year from 1987 - 2005.
Mizzou has agreed to a home and home with Purdue for 2017-2018 now that the SEC is requiring one OOC opponent from a power 5 conference. Probably felt IU was too risky so they came to an agreement with the Boilermakers who were coming off a 1-11 season.