Pats & Genos are for tourists. Go to Dellassandros or John's Roast Pork are the best two sandwhiches in Philly. Also Fette Sau (BBQ) is great and it's located right next to Frankford Beer Hall.
-Yards Brewery is cool
-Art Museum, Kelly Drive, Muetter Museum, Manayunk for drinks, Chestnut Hill or the Navy Yard.
Also Mitchell & Ness is located in city center and worth it if you are into throwback swag.