The Crush, Texas train crashing event was pretty spectacular. At the time of the crash, it was the largest city in Texas (50,000+).
There's a good, quick read about it, here, though the facts differ slightly from other articles: http://www.lsjunction.com/facts/crush.htm
There's also an interview with one of the engineers from the Katy Railroad in the web archives: http://web.archive.org/web/20040528020558/http://home.flash.net/~cymartin/crossxroads/68crush.htm
Ironically, despite the tragedy involved, this type of train-crashing event was subsequently recreated many times in the following years, including a demo at a California State Fair nearly 20 years later (1913), with slightly better (less fatal) results.