There's so many choices, but I have to say Texas-Texas Tech from 2008. I remember the feeling of euphoria I felt when Crabtree broke the tackle and scored on the last play, and seeing the look of defeat on Colt McCoy's face. It was tremendous. A very, very close second would be Texas-USC in the '05 Natty, seeing the Trojans go down in the final seconds was a true thing of beauty.
But what is your favorite non-Buckeye game?